The CyberKnife is a dedicated stereotactic radiosurgery and stereotactic radiotherapy system which is distinguished for its innovative design and ground-breaking technology. It was the first system to obviate the need for a mechanical fixation frame for intracranial treatments by utilizing real time image-guided technology coupled with a robotic manipulator. With CyberKnife, radiosurgery can be applied for the treatment of lesions (malignant, benign, or functional) anywhere in the body upon clinical indication.